منابع مشابه
Evaluation of sulfobutylether-β-cyclodextrin (SBECD) accumulation and voriconazole pharmacokinetics in critically ill patients undergoing continuous renal replacement therapy
INTRODUCTION Intravenous (IV) voriconazole is not recommended in patients with creatinine clearance <50 ml/min to avoid potentially toxic accumulation of sulfobutylether-β-cyclodextrin (SBECD). The purpose of this study was to evaluate the pharmacokinetics of SBECD, voriconazole, and voriconazole N-oxide in critically ill patients undergoing continuous renal replacement therapy (CRRT) and to de...
متن کاملSevoflurane-Sulfobutylether-β-Cyclodextrin Complex: Preparation, Characterization, Cellular Toxicity, Molecular Modeling and Blood-Brain Barrier Transport Studies.
The objective of the present investigation was to study the ability of sulfobutylether-β-cyclodextrin (SBEβCD) to form an inclusion complex with sevoflurane (SEV), a volatile anesthetic with poor water solubility. The inclusion complex was prepared, characterized and its cellular toxicity and blood-brain barrier (BBB) permeation potential of the formulated SEV have also been examined for the pu...
متن کاملNovel β-cyclodextrin–eosin conjugates
Eosin B (EoB) and eosin Y (EoY), two xanthene dye derivatives with photosensitizing ability were prepared in high purity through an improved synthetic route. The dyes were grafted to a 6-monoamino-β-cyclodextrin scaffold under mild reaction conditions through a stable amide linkage using the coupling agent 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride. The molecular conjuga...
متن کاملEncapsulation Mechanism of Oxyresveratrol by β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin and Computational Analysis.
In this study, the encapsulation mechanism of oxyresveratrol and β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) was studied. As this research shows, oxyresveratrol and two cyclodextrins (CDs) were able to form inclusion complexes in a 1:1 stoichiometry. However, the interaction with HP-β-CD was more efficient, showing up as higher encapsulation constant (KF) (35,864.72 ± 3415....
متن کاملPhase Solubility Studies on Oral Antidiabetic Drugs with Β-cyclodextrin and Hp - Β Cyclodextrin
Nateglinide(NTG), Repaglinide(RPG), and Glimepiride(GMP) are antidiabetic drugs. These antidiabetic drugs are poorly soluble in water, which affect the bioavailability. In the present work, complex formation of all the three drugs with b-cyclodextrin (b-CD) and Hydroxy propyl bcyclodextrin (HPb-CD) and then the possibility of improving the solubility of NTG, RPG and GMP by complexation with b-C...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2020
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2020.119396